Mauricio Pochettino’s men were given a helping hand by a nightmarish display from Lille goalkeeper Ivo Grbic at the Stade Pierre-Mauroy.
It was the perfect response for PSG after their French Cup exit on penalties at the hands of Nice in midweek.
Lille are languishing down in 11th place after a seventh defeat of their title defence.
The hosts needed to get something from the game to move into the top half of the table, but they made a calamitous start.
Grbic somehow failed to gather in Nuno Mendes‘ low cross despite being under no pressure, and Danilo duly stabbed into an empty net to give PSG a 10th-minute lead.
Hatem Ben Arfa, making his first start since last April after his surprise move to Lille, set up Sven Botman to equalise before the half-hour mark.
But PSG were back in front in the 32nd minute as Grbic totally missed Messi’s corner and Kimpembe bundled home from close range.
Messi grabbed his first goal of 2022 in slightly fortuitous circumstances, as a clearance ricocheted of his shins and played him in on goal.
Grbic rushed out to close the angle, but the seven-time Ballon d’Or winner coolly dinked the ball into the net to score his second Ligue 1 goal.
PSG quickly put paid to any thoughts of a second-half comeback from Lille as Danilo scored his second goal.
The 26-year-old Grbic’s day took another turn for the worse as he followed a fumble with a poor clearance, which Leandro Paredes squared for Danilo to fire a long-range effort into the bottom corner.
There was nothing the goalkeeper could do to keep about PSG’s fifth goal midway through the second half, though, as Mbappe unleashed a magnificent, curling strike from outside the area into the top corner.
Earlier on Sunday, Nice missed the chance to retake second place in the table from Marseille as they slumped to a 1-0 home defeat by struggling Clermont.
Rennes then took advantage, beating Brest 2-0 to move up to fifth, just five points behind Nice in the third and final Champions League spot.
Bordeaux’s dreadful season continued as they dropped into the bottom two after an embarrassing 5-0 thrashing at Reims